It is possible that the hotel was built sometime in the 1910's. Mairfair used to have been a luxury hotel for weathly people and also tourists. The hotel might have been a major hotspot for bussisness men cause the hotel has a bar, lounge, and restaurant.
Mayfair Hotel used to be open to the pubilc before the outbreak began and the a part of the hotel was sealed-off where Thomas Eichhorst used to torture many unnamed people and turn them into the undead, including Dutch Velders, but she managed to escape the building with the help of Nora Martinez, Ephraim Goodweather, and Vasiliy Fet. The hotel is currently being used as a headquarters for the New York National Guard and as hot spot for law enforcement as seen in Bad White.